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Recombinant 2019-nCoV S2 Protein

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ATEP02475COV
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Summaryicon
Catalog#
ATEP02475COV
description
Recombinant SARS-CoV-2 S2 Protein is produced by E.coli expression system and the target gene encoding Ser686-Pro1213 is expressed with N-His Tag
Expression system
E.coli
Species
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Accession #
QHD43416.1
Alternative names
S2 protein,Spike glycoprotein Subunit2,S glycoprotein Subunit2,Spike protein S2
Predicted Molecular Mass
60.14kDa
Purity
>90% as determined by SDS-PAGE
Endotoxin level
Please contact with the lab for this information.
Formulation
Lyophilized. Lyophilized from PBS pH7.4，0.02%NLS,1mM EDTA, 4%trehalose，1% mannitol.
Shipping
In general, proteins are shipped out with blue ice unless customers require otherwise.
Stability &Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Reconstitution
Reconstitute in sterile water for a stock solution.
Application
Immunogen
SDS-PAGE imageicon
    Backgroundicon
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    Product performanceicon
    Form
    Recombinant 2019-nCoV S2 Protein
    Tested Pictureicon
      Noteicon
      For research use only.

      Guarantee and Disclaimer:

      After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

      When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

      When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

      The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.

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