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Anti STAT3 polyclonal antibody

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product nameicon
Anti STAT3 polyclonal antibody
catalog No.icon
ATP011
Categoryicon
Primary antibody
Hosticon
Rabbit
Species specificityicon
Human, Mouse, Rat
Tested applicationsicon
WB:1:2000~1:8000,ICC:1:50~200,IHC:1:50~100
Clonalityicon
Polyclonal
Conjugationicon
Unconjugated
Immunogenicon
Recombinant protein of human STAT3(Met1-Met770).
Alternative Namesicon
Signal transducer and activator of transcription 3,Acute-phase response factor,STAT3,APRF
Uniprot IDicon
P40763
Formicon
Liquid
Buffericon
PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
Storageicon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
Concentrationicon
0.76mg/ml
Isotypeicon
IgG
MWicon
88kDa
Purityicon
Antigen affinity purification
WB,ICC,IHC
    PubMed:10688651;PubMed:12359225;PubMed:12873986;PubMed:15194700
    Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human STAT3. STAT3 exists three isoforms and the molecular weight of each isoform respectively is 83 kDa, 87 kDa and 88 kDa.

    Guarantee and Disclaimer:

    After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

    When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

    When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

    The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.

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