Anti CCND1 polyclonal antibody

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ATP008
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product nameicon
Anti CCND1 polyclonal antibody
catalog No.icon
ATP008
Categoryicon
Primary antibody
Hosticon
Rabbit
Species specificityicon
Human,other species was not test
Tested applicationsicon
ICC:1:50~200,IHC:1:50~100
Clonalityicon
Polyclonal
Conjugationicon
Unconjugated
Immunogenicon
Recombinant protein of human CCND1(Lue65-Arg245).
Alternative Namesicon
G1/S-specific cyclin-D1,CCND1,B-cell lymphoma 1 protein,BCL-1,BCL-1 oncogene,PRAD1 oncogene
Uniprot IDicon
P24385
Formicon
Liquid
Buffericon
PBS,pH7.4,containing 0.05% proclin300,50% glycerol.
Storageicon
Use a manual defrost freezer and avoid repeated freeze thaw cycles.Store at 4°C for frequent use.Store at -20 to -80 °C for twelve months from the date of receipt.
Concentrationicon
0.63mg/ml
Isotypeicon
IgG
MWicon
34kDa
Purityicon
Antigen affinity purification
ICC,IHC
    PMID: 9106657;PMID:15241418;PMID:16569215;PMID:18417529
    CCND1 (cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma (MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

    Guarantee and Disclaimer:

    After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

    When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

    When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

    The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.