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Recombinant 2019-nCoV NSP1

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ATEP02461COV
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Summaryicon
Catalog#
ATEP02461COV
description
Recombinant SARS-CoV-2 NSP1 is produced by E.coli expression system and the target gene encoding Met1-Gly180 is expressed with N-His Tag
Expression system
E.coli
Species
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Accession #
YP_009725297.1
Alternative names
SARS-CoV 2 nsp1,SARS-CoV 2 Leader protein
Predicted Molecular Mass
21.94kDa
Actual Molecular Mass
22-23kDa
Purity
>90% as determined by SDS-PAGE
Endotoxin level
Please contact with the lab for this information.
Formulation
Supplied as lyophilized from PBS, pH7.4,0.02%NLS,1mM EDTA, 4%trehalose,1% mannitol.
Shipping
In general, proteins are shipped out with blue ice unless customers require otherwise.
Stability &Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
Reconstitution
Reconstitute in sterile water for a stock solution.
Application
Immunogen
SDS-PAGE imageicon
    Backgroundicon
    The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
    Product performanceicon
    Form
    Recombinant 2019-nCoV NSP1
    Noteicon
    For research use only.

    Guarantee and Disclaimer:

    After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

    When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

    When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

    The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.

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