Tocilizumab

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ATAD00661
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Catalog No.icon
ATAD00661
INN (International Nonproprietary Name)icon
Tocilizumab
Purityicon
>95%
SDS-PAGE imageicon
    Concentrationicon
    2.05mg/ml
    Formulationicon
    PBS buffer PH7.4
    Sourceicon
    CHO cells
    Endotoxin levelicon
    Please contact with the lab for this information.
    Noteicon
    For research use only .
    Descriptionicon
    Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody,prevents binding of IL-6 to the IL-6R,thereby inhibiting both classic and trans-signaling.Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis.
    Bioactivityicon
      Alternative namesicon
      Atlizumab,MRA/R-1569/RHPM-1/RO-4877533
      Specificity target name;speciesicon
      IL-6R
      Activity in vitroicon
      Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-100 ng/mL; 24 hours, 48 hours) inhibits the cell proliferation (growth rate) in a dose-dependent manner, growth rate by HACM is reduced almost completely by 100 ng/mL tocilizumab.
      Tocilizumab (Anti-Human IL6R, Humanized Antibody) (0.001-10,000 μg/ml; 2 days) inhibits Ba/F3-gp130-IL-6R cell proliferation stimulated with hIL-6 with an IC50 of 13.5 ng/ml.
      Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1 μM; 6 hours) reduces the phosphorylation of STAT3 in vitro consistent with in vivo SAS cells.
      Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-5 μM; 24 hours) significantly reduces VEGF mRNA expression in SAS cells with serum-free medium.
      Receptor identificationicon
      IgG1
      CASicon
      375823-41-9
      Storageicon
      Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
      Store at +4°C short term (1-2 weeks).
      Store at -20 °C 12 months.
      Store at -80°C long term.

      Guarantee and Disclaimer:

      After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

      When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

      When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

      The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.