Pertuzumab

ATAD00025

Pertuzumab

>95%

1.74 mg/ml

PBS buffer PH7.4

CHO cells

Please contact with the lab for this information.

For research use only .

Pertuzumab (anti-HER2),a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors,impairs the ability of HER2 to bind to other members of the HER family.

OMNITARG,rhuMAB 2C4

ERBB2/EGFR2/CD340[Homo sapiens]

Pertuzumab (anti-HER2) significantly inhibits the HRG-α-stimulated cellular growth of the 11_18 cells. Pertuzumab blocks HRG-α-stimulated phosphorylation of HER3, mitogen-activated protein kinase (MAPK), and Akt. In contrast, pertuzumab fails to block epidermal growth factor (EGF)-stimulated phosphorylation of EGF receptor (EGFR) and MAPK.Immunoprecipitation shows that pertuzumab inhibited HRG-α-stimulated HER2/HER3 heterodimer formation. HRG-α-stimulated HER3 phosphorylation is also observed in the PC-9 cells co-overexpressing EGFR, HER2, and HER3, but the cell growth is neither stimulated by HRG-α nor inhibited by pertuzumab. Pertuzumab binds to ErbB2 near the center of domain II, sterically blocking a binding pocket necessary for receptor dimerization and signaling. Pertuzumab is specific for human ErbB2 and does not bind to rodent ErbB2 (neu) with detectable affinity.

Humanized

IgG1-kappa

148000.00 Da

380610-27-5

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Store at +4°C short term (1-2 weeks).
Store at -20 °C 12 months.
Store at -80°C long term.

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After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

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