AtaGenix

Ruplizumab

  • 1
  • 2
ATAD00002
-
+
futures
Inquiry
  • Product Details
  • Bioactivity
  • Chemistry
  • How to order
  • Instructions
Catalog No.icon
ATAD00002
INN (International Nonproprietary Name)icon
Ruplizumab
Purityicon
>95%
SDS-PAGE imageicon
    Concentrationicon
    1mg/ml
    Formulationicon
    PBS buffer PH7.4
    Sourceicon
    CHO cells
    Endotoxin levelicon
    Please contact with the lab for this information.
    Noteicon
    For research use only .
    Descriptionicon
    Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive drug and is a component of Antova.Ruplizumab is an anti-CD40L monoclonal antibody.The binding of CD40 to its ligand,CD40L is a critical element in T cell activation.In systemic lupus erythematosus,CD40L is over-expressed on T cells, B cells and monocytes.
    Alternative namesicon
    BG-9588,hu5c8
    Specificity target name;speciesicon
    CD40LG[Homo sapiens]
    Target informationicon
    Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
    Speciesicon
    Humanized
    Receptor identificationicon
    IgG1-kappa
    MVicon
    145448.00 Da
    CASicon
    220651-94-5
    Storageicon
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    Store at +4°C short term (1-2 weeks).
    Store at -20 °C 12 months.
    Store at -80°C long term.

    Guarantee and Disclaimer:

    After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

    When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

    When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

    The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.