AtaGenix

PVHL mouse monoclonal antibody

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ATDA00077
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product nameicon
pVHLmouse monoclonal antibody
catalog No.icon
ATDA00077
Categoryicon
Primary antibody
Hosticon
Mouse
Species specificityicon
This antibody detects endogenous levels of human pVHL. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
Tested applicationsicon
IHC-p
Clonalityicon
Monoclonal
Immunogenicon
Synthesized peptide derived from human pVHL.
Alternative Namesicon
Von Hippel-Lindau disease tumor suppressor,Protein G7,Pvhl
Uniprot IDicon
P40337
Formicon
Liquid
Buffericon
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storageicon
Stored at -20℃.Avoid repeated freeze-thaw cycles.
Concentrationicon
1 mg/ml
Isotypeicon
IgG3,Kappa
IHC-p:1:100-1:500
Von Hippel-Lindau tumor suppressor(VHL) Homo sapiens Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors.A germline mutation of this gene is the basis of familial inheritance of VHL syndrome.The protein encoded by this gene is a component of the protein complex that includes elongin B,elongin C,and cullin-2,and possesses ubiquitin ligase E3 activity.This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF),which is a transcription factor that plays a central role in the regulation of gene expression by oxygen.RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Guarantee and Disclaimer:

After receiving the product, if finds that the product is mismatched, damaged or missing components, please keep the original package and submit the objection to the company by mail within seven working days. Failure to file an objection within the time limit is considered qualified.

When the buyer keeps the product, it should be kept in accordance with the storage conditions shown in the product label and the manual. If the product quality is caused by improper storage, it will not be guaranteed.

When the buyer tests the product, they should be submitted by the beginning of use when found the quality issue, rather than when the product was used or used up, in order to prepare our products for recycling and confirm the quality of the products. If it is the quality problem, our company is responsible for exchange or return. In the event of a claim, our company will compensate the discretion within the scope of the product price limit and will not accept any part of the value of the product itself. Since the date of receipt, the product has not been reflected for more than three months and should not be returned.

The products provided by our company are for research use only and should not be used for clinical diagnosis or treatment. If a unit or individual changes the use of our products without authorization, we will not bear any responsibility.